The Broadest Perspective
Theoretically, the most optimal human condition would be to know a total, all-inclusive reality in full. The human mind, however, is always finite, so it can only absorb a certain portion of reality on a local scale. Everything else is always beyond our reach, regardless of our axioms.
The fact that our local knowledge keeps expanding over time, eventually it makes obvious that the total reality is not within our reach - something else is always further out. Acknowledging that reality within our access is just a part of a much broader total reality is therefore a logical conclusion.
No matter how advanced our knowledge may become, it always depends on unverifiable assumptions as to the greater level of reality. For practical purposes, fairly stable local factors may be assessed, but there are as well more distant factors in space and time - unknown and possibly endless.
By acquiring further empirical data it is possible to keep broadening our perspectives for a while. However, every new discovery simply moves the overall question marks further out, and never eliminates them. Anything that is objectively established as most fundamental, later on may be fully negated in light of the unknown factors from the broader range. Therefore, acquiring objective knowledge never eliminates more underlying questions.
At the very best, we can ascertain a somewhat broader or deeper set of correlations, but it will always continue to be only partial. Despite scientific achievements, there is no way of knowing whether the most permanent condition within our reach is primary and truly universal, or perhaps quite unique and warranted only by some coincidental factors somewhat beyond our reach. Such a hierarchical rank can continue on well beyond our human access, heading potentially towards infinity.
For instance, it is entirely possible that our physical universe with all of its galaxies is quite exceptional and impermanent. Theoretically, it may be no more than a unique type of subatomic particle with respect to the much broader dimension that is still unknown.
Likewise, our subatomic particles that have been established recently here on earth may well depend on much deeper circumstances that are still undiscovered. Theoretically, such tiny particles may be entire galaxies with respect to the still unknown much smaller dimension. Thus, everything within our reach always relies on further unknown factors from opposite directions.
Independent thinkers know that things are what they are based on further and more underlying sources. At some point, however, the total, potentially infinite reality must have an overall supreme foundation, which warrants virtually everything. If not for a certain ultimately most fundamental law, reality would not be what it is, including ourselves as conscious beings, having fundamental nature.
Therefore, the logical conclusion is that although we have absolutely no direct knowledge as to what underlies all existence, a certain most crucial unknown factor must necessarily underlie it nevertheless.
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